What are the best 375 Ruger handloads for use in Alaska...260/270 gr or 300 gr?? If I handload my 416 Rem with 350 gr bullets (@ 2540 fps) I can achieve the same ballistics trajectory as the 300 gr 375 Ruger loaded @ 2725 fps. At 250 yds both bullets are about 4 inches low. Not bad at all. That way I can shoot either rifle the same. "Point blank range" would be 250 yds for both rifles. About the only difference is the 416 Rem is a pound heavier.