My .280 Remington loves these things with some H414 behind it. It shoots sub MOA groups at 100 yards with them. I was thinking about taking that load with me to hunt Caribou. I know ballistic tips are not the best big game hunting bullets but I did a little research and saw that Nosler ballistic tips hold together pretty well and can take big game. I have also seen that a lot of people take cariobu with a .223 and 22-250. I know shot placement is everything in those cartridges on big game but I personally only take behind the shoulder shots. Has anyone had any luck with similar cartridges on caribou and do you think the 120 grain ballistic tip is enough bullet to get into heart and lungs on shots out to 300 yards?