Here's one we can all chew on; it comes up pretty often and I think with the influx of new folks here it's worth approaching in a different way. Let's talk about your top three choices of centerfire caliber for Alaska-Yukon moose. Once this percolates a bit I may post a poll on the favored calibers and see what we get.
Here are my choices, in order of preference, and why.
1. 7mm Remington Magnum. I carried one of these for over 20 years before started guiding, killed deer, elk, sheep, goat, black bear and moose with it. I always knew what it would do at various yardages and that particular rifle (it was a Ruger) was a real tack driver. Quit carrying it when I started guiding because I thought it was inadequate as a sure-fire bear stopper. Anyway, a sure moose killer, and a very flat shooter for those longer shots that sometimes present few alternatives.
2. .338 Win. Mag. I don't own one, but I have seen plenty of moose killed with them. A very nice flat shooter with good bullet selection.
3. 30.06. I have one, rarely use it, but you get an excellent choice of bullets for this caliber and it will surely kill a moose.
Having said all that, I know that these are not the best choices for bear protection, a sermon I have preached here many times. I'm not asking about bear protection here, but simply what you would prefer to hunt moose with.