Here is a spike that was shot in the head. From the position the moose was facing the shot was right between the eyes as intended. Went only about an inch low but that was enough to miss the brain.
The moose landed on its lower back as it fell back so fast that it missed landing on its rear. Not a twitch or anything. Then 10 seconds later it got right up and ran away(took another hit at 70 yards from a 41 mag which dislocated the front shoulder). Only made it 80 yards bleeding out and stopped and went down. Lifted its head once more but got the last shot between the eyes from 6 feet above as no more chasing was wanted.
A lesser bullet may not have had the same outcome. This was a 375 Barnes XPB from a 500 S&W Handi-rifle at 20 feet (1890 FPS). The bullet completely penetrated the head and missed the vertebrea by a hair. Left a blood trail that could have been followed by the blind in the rain.