I think that the effects of placing a bullet 3" one way or 3" the other from any of the popular big bore handguns makes the question of " which is best " a waste of time . I would not set aside any Ruger .44 ( shooting heavy , hard cast ) to buy a .454 ( I own two ) or .500 Smith . I shot a black bear behind my cabin that was sneaking up on my wife and kid and got complete penetration with a hot .44 load with 325 gr. cast slug and rolled the bear over , would a .500 have done better ? Only one instance but I suspect any tough , large caliber bullet works almost as well as any other , give or take 300 f.p.s. .