The 45 Colt Ruger only loads go here also I think. The evolution of 45/454/460 is like 38 Special to 357 Magnum to 357 Maximum, each step up is a longer version of almost the same thing and guns for each bigger round will fire the smaller/shorter rounds just fine.
We know well loaded guns in the 41Mag/44mag/45 Colt class can shoot clear through a moose end to end so why would you want anything more is the normal question. Especially coupled with how difficult they can be to shoot well and how heavy the guns can be. There are 3 reasons in my mind, all are arguable and depend a lot on how you hunt.
The first is more a bear defense matter than hunting, compensating for velocity lost to a compact firearm. A stubby 454 Alaskan has a lot more punch than 41/44/45 from the same size barrel . . .
Next is knockdown or stopping power. We know the 41/44/45 can penetrate something like 4 foot and we never need more than that, heck thatís enough for a heart/lung on elephant. But this penetration comes with solid non expanding bullets and large body beasts die well to these but often not where they were shot. Moose love water and if there is any around he will head for it making recovery not very fun at all. With more power expanding bullets can be used while still getting plenty of penetration but with a much larger hole and a critter that is likely to travel less . . . the handgun starts to kill a little more like a rifle if you will.
Last is range, if you fire a bullet faster you get further out before the speeds drop off to below an effective velocity. This matters little for a deer/elk/moose hunter, odds of shooting past 100 yards on these is slim. But for caribou, sheep, goat, and antelope down south it can matter a lot. Itís much harder to get right on top of these critters and another 25 or 50 yards of effective range and confidence that it will work there can be the difference in drawing blood or a long hike to camp saying almost. 460S&W takes that to a complete new level. You can push a 200g Hornady XTP over 2500fps from an S&W 460XVR handgun. Think about that and look at some 308/30-06 200g velocities numbers, no it wonít fly as good as a 30cal but it does better than you may think.
I hunt mostly with a Smith 460V myself and take moose most years with it, superbly accurate and powerful. The only drawback is that itís a big hunk of iron but in a Diamond-D chest rig it does just fine.
Now who is going to start the 480Ruger/475Linebaugh thread? Iíll do it tonight if someone else (Paul H maybe) doesnít want to.